Dab tsi yog qhov cuam tshuam ntawm cov organic acids thiab acidified glycerides hauv "txwv tsis pub ua haujlwm thiab txo qis"?
Txij li thaum European txwv tsis pub siv tshuaj tua kab mob loj hlob (AGPs) hauv 2006, kev siv cov organic acids hauv cov khoom noj tsiaj tau dhau los ua qhov tseem ceeb hauv kev lag luam pub. Lawv qhov kev cuam tshuam zoo rau kev noj zaub mov zoo thiab kev ua haujlwm ntawm cov tsiaj tau nyob ib puag ncig rau ntau xyoo lawm, vim tias lawv tau nce kev nyiam ntawm kev lag luam pub.
Cov organic acids yog dab tsi?
Organic acids" yog hais txog tag nrho cov kua qaub hu ua carboxylic acids ua rau ntawm lub cev pob txha uas tuaj yeem hloov kho lub cev nqaij daim tawv ntawm cov kab mob, ua rau cov metabolic txawv txav uas tiv thaiv kev loj hlob thiab ua rau tuag taus.
Yuav luag tag nrho cov organic acids siv nyob rau hauv cov tsiaj noj zaub mov (xws li formic acid, propionic acid, lactic acid, acetic acid, sorbic acid los yog citric acid) muaj ib tug aliphatic qauv thiab yog lub zog rau lub hlwb. Piv txwv li,
benzoic acidyog tsim los ntawm cov nplhaib uas muaj ntxhiab thiab muaj qhov sib txawv metabolic thiab nqus cov khoom.
Kev ntxiv cov organic acids ntawm cov koob tshuaj kom zoo hauv cov tsiaj pub tuaj yeem ua rau lub cev hnyav, txhim kho kev hloov pauv thiab txo cov colonization ntawm cov kab mob hauv plab.
1, txo tus nqi pH thiab buffering peev nyob rau hauv pub nrog rau cov tshuaj tua kab mob thiab tshuaj tua kab mob.
2, los ntawm kev tso tawm hydrogen ions nyob rau hauv lub plab kom txo tau cov pH nqi, yog li activating pepsinogen rau pepsin thiab txhim kho protein digestibility;
3. Inhibition ntawm gram-negative kab mob nyob rau hauv lub plab zom mov.
4, nruab nrab metabolites - siv los ua lub zog.
Qhov ua tau zoo ntawm cov organic acid hauv inhibiting microbial kev loj hlob nyob ntawm nws tus nqi pKa, uas piav qhia txog pH ntawm cov kua qaub ntawm 50% hauv nws daim ntawv dissociated thiab undissociated. Qhov kawg yog txoj hauv kev uas cov organic acids muaj cov tshuaj tua kab mob. Nws tsuas yog thaum cov organic acids nyob rau hauv lawv daim ntawv undissociated uas lawv muaj peev xwm dhau los ntawm cov phab ntsa ntawm cov kab mob thiab cov fungi thiab hloov lawv cov metabolism uas lawv muaj peev xwm tiv thaiv kab mob. Yog li, qhov no txhais tau hais tias kev siv tshuaj tua kab mob ntawm cov organic acids yog siab dua nyob rau hauv acidic tej yam kev mob (xws li hauv plab) thiab txo qis ntawm nruab nrab pH (hauv txoj hnyuv).
Yog li ntawd, cov organic acids uas muaj pKa siab muaj nuj nqis yog cov acids tsis muaj zog thiab muaj txiaj ntsig zoo ntawm cov tshuaj tua kab mob hauv cov khoom noj vim tias muaj ntau dua ntawm cov ntaub ntawv tsis sib xws tam sim no nyob rau hauv pub, uas tuaj yeem tiv thaiv pub los ntawm cov kab mob thiab cov kab mob.
Acidified glycerides
Nyob rau xyoo 1980, tus kws tshawb fawb Asmeskas Agre tau tshawb pom cov cell membrane protein hu ua aquaporin. Kev tshawb pom ntawm cov dej ntws qhib qhov chaw tshiab ntawm kev tshawb fawb. Tam sim no, cov kws tshawb fawb tau pom tias aquaporins muaj nyob hauv cov tsiaj, nroj tsuag thiab kab mob.
Los ntawm cov synthesis ntawm propionic acid thiab butyric acid thiab glycerol, α-monopropionic acid glycerol ester, α-monobutyric acid glycerol ester, los ntawm thaiv cov kab mob thiab fungi glycerol channel, cuam tshuam nrog lawv lub zog tshuav nyiaj li cas thiab daim nyias nyias dynamic tshuav nyiaj li cas, kom lawv poob lub zog qhov chaw, thaiv lub zog synthesis thiaj li tsis muaj cov kab mob zoo, ua rau cov kab mob zoo li qub.
Tus nqi pKa ntawm cov organic acids yog lawv cov nyhuv inhibitory ntawm cov kab mob. Qhov kev txiav txim ntawm cov organic acids feem ntau yog nyob ntawm koob tshuaj, thiab qhov ntau ntawm cov khoom xyaw nquag mus txog qhov chaw ntawm qhov kev txiav txim, qhov ntau dua qhov yuav tsum tau ua. Qhov no siv tau ob qho tib si rau kev khaws cia pub thiab rau kev noj haus thiab kev noj qab haus huv cuam tshuam rau tsiaj. Yog tias muaj cov kua qaub muaj zog dua, cov ntsev ntawm cov organic acids tuaj yeem pab txo qis lub peev xwm ntawm cov khoom noj thiab tuaj yeem muab cov anions rau kev tsim cov organic acids.
Acidified glycerides nrog cov qauv tshwj xeeb, α-monopropionate thiab α-monobutyric glycerides, muaj cov kab mob zoo kawg nkaus rau Salmonella, Escherichia coli thiab lwm cov kab mob gram-tsis zoo thiab clostridium los ntawm inhibiting dej-glycerine channel ntawm cov kab mob, thiab cov kab mob no tsis txwv los ntawm tus nqi pKa; Nws tsis tsuas yog ua lub luag haujlwm hauv txoj hnyuv, tab sis kuj tseem muaj cov kab mob luv luv fatty acid glyceride absorbed ncaj qha mus rau hauv cov ntshav los ntawm txoj hnyuv, thiab mus txog ntau yam kab mob ntawm lub cev los ntawm cov hlab ntsha portal kom zoo dua tiv thaiv thiab tswj cov kab mob kab mob.
Post lub sij hawm: Aug-22-2024 
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