Cov teebmeem ntawm cov organic acids thiab acidified glycerides hauv "kev tiv thaiv txwv tsis pub thiab txo qis kev tiv thaiv" yog dab tsi?
Txij li thaum European txwv tsis pub siv cov tshuaj tua kab mob loj hlob (AGPs) hauv xyoo 2006, kev siv cov organic acids hauv kev noj zaub mov tsiaj tau dhau los ua qhov tseem ceeb hauv kev lag luam pub tsiaj. Lawv qhov cuam tshuam zoo rau qhov zoo ntawm cov zaub mov thiab kev ua tau zoo ntawm cov tsiaj tau muaj nyob rau ntau xyoo lawm, vim tias lawv tau nyiam cov xim ntawm kev lag luam pub tsiaj ntau zuj zus.
Cov organic acids yog dab tsi?
Cov kua qaub organic "yog hais txog txhua cov kua qaub hu ua carboxylic acids uas ua rau ntawm cov pob txha carbon uas tuaj yeem hloov pauv cov qauv ntawm cov kab mob, ua rau muaj kev tsis zoo ntawm cov metabolism uas tiv thaiv kev loj hlob thiab ua rau tuag.
Yuav luag txhua cov organic acids siv rau hauv kev noj haus tsiaj (xws li formic acid, propionic acid, lactic acid, acetic acid, sorbic acid lossis citric acid) muaj cov qauv aliphatic thiab yog cov khoom siv zog rau cov cell. Qhov sib txawv,
benzoic acidyog tsim los ntawm cov nplhaib aromatic thiab muaj cov khoom sib txawv ntawm kev zom zaub mov thiab kev nqus.
Kev ntxiv cov organic acids ntawm cov koob tshuaj siab tsim nyog hauv cov tsiaj pub tuaj yeem ua rau lub cev hnyav dua, txhim kho kev hloov pauv zaub mov thiab txo qhov kev loj hlob ntawm cov kab mob hauv txoj hnyuv.
1, txo qhov pH tus nqi thiab buffering peev xwm hauv pub nrog rau cov teebmeem antibacterial thiab antifungal.
2, los ntawm kev tso tawm cov hydrogen ions hauv plab kom txo qhov pH, yog li ua kom pepsinogen ua haujlwm los tsim pepsin thiab txhim kho kev zom zaub mov protein;
3. Kev tiv thaiv cov kab mob gram-negative hauv txoj hnyuv.
4, cov metabolites nruab nrab - siv ua lub zog.
Qhov ua tau zoo ntawm cov organic acid hauv kev tiv thaiv kev loj hlob ntawm cov kab mob nyob ntawm nws tus nqi pKa, uas piav qhia txog pH ntawm cov kua qaub ntawm 50% hauv nws daim ntawv dissociated thiab undissociated. Qhov kawg yog txoj hauv kev uas cov organic acids muaj cov khoom antimicrobial. Tsuas yog thaum cov organic acids nyob rau hauv lawv daim ntawv undissociated uas lawv tuaj yeem hla dhau phab ntsa ntawm cov kab mob thiab cov fungi thiab hloov lawv cov metabolism uas lawv muaj peev xwm antimicrobial. Yog li, qhov no txhais tau tias cov tshuaj tua kab mob ntawm cov organic acids yog siab dua nyob rau hauv cov xwm txheej acidic (xws li hauv plab) thiab txo qis ntawm pH nruab nrab (hauv plab hnyuv).
Yog li ntawd, cov organic acids uas muaj pKa siab yog cov acids uas tsis muaj zog thiab muaj cov tshuaj tua kab mob zoo dua hauv cov pub vim muaj feem pua ntau ntawm cov qauv tsis sib cais uas muaj nyob hauv cov pub, uas tuaj yeem tiv thaiv cov pub los ntawm cov kab mob fungi thiab cov kab mob me me.
Cov kua qaub glyceride
Xyoo 1980, tus kws tshawb fawb Asmeskas Agre tau tshawb pom ib qho protein ntawm daim nyias nyias ntawm lub cell hu ua aquaporin. Kev tshawb pom cov kwj dej qhib ib qho chaw tshawb fawb tshiab. Tam sim no, cov kws tshawb fawb tau pom tias aquaporins muaj ntau nyob rau hauv cov tsiaj, cov nroj tsuag thiab cov kab mob me me.
Los ntawm kev tsim cov propionic acid thiab butyric acid thiab glycerol, α-monopropionic acid glycerol ester, α-monobutyric acid glycerol ester, los ntawm kev thaiv cov kab mob thiab cov pwm glycerol channel, cuam tshuam rau lawv qhov sib npaug ntawm lub zog thiab qhov sib npaug ntawm daim nyias nyias, yog li lawv poob qhov chaw muaj zog, thaiv kev tsim hluav taws xob kom ua si zoo rau cov kab mob bactericidal, thiab tsis muaj cov tshuaj seem.
Tus nqi pKa ntawm cov organic acids yog lawv cov nyhuv inhibitory rau cov kab mob me me. Cov kev ua ntawm cov organic acids feem ntau yog nyob ntawm qhov koob tshuaj, thiab ntau ntawm cov khoom xyaw nquag mus txog qhov chaw ua haujlwm, qhov siab dua qhov kev ua haujlwm xav tau. Qhov no muaj txiaj ntsig zoo rau kev khaws cia cov zaub mov thiab rau cov khoom noj khoom haus thiab kev noj qab haus huv rau cov tsiaj. Yog tias muaj cov kua qaub muaj zog dua, cov ntsev ntawm cov organic acids tuaj yeem pab txo qhov muaj peev xwm ntawm cov zaub mov thiab tuaj yeem muab cov anions rau kev tsim cov organic acids.
Cov kua qaub glycerides uas muaj cov qauv tshwj xeeb, α-monopropionate thiab α-monobutyric glycerides, muaj cov nyhuv bactericidal zoo kawg nkaus rau Salmonella, Escherichia coli thiab lwm yam kab mob gram-negative thiab clostridium los ntawm kev txwv tsis pub cov dej-glycerine channel ntawm cov kab mob, thiab cov nyhuv bactericidal no tsis txwv los ntawm pKa tus nqi thiab PH tus nqi; Nws tsis yog tsuas yog ua lub luag haujlwm hauv txoj hnyuv xwb, tab sis kuj tseem muaj cov roj fatty acid luv luv glyceride no raug nqus ncaj qha rau hauv cov ntshav los ntawm txoj hnyuv, thiab ncav cuag ntau qhov chaw kis kab mob ntawm lub cev los ntawm cov hlab ntsha portal kom tiv thaiv thiab tswj tau cov kab mob systemic zoo dua.
Lub sijhawm tshaj tawm: Lub Yim Hli-22-2024 
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