Tau ntau xyoo lawm, cov kua qaub butyric tau siv rau hauv kev lag luam pub tsiaj kom txhim kho kev noj qab haus huv ntawm txoj hnyuv thiab kev ua haujlwm ntawm cov tsiaj. Txij li thaum thawj zaug sim ua nyob rau hauv xyoo 1980, muaj ntau tiam neeg tshiab tau raug qhia los txhim kho kev tuav cov khoom thiab nws cov kev ua tau zoo.

Tau ntau xyoo lawm, butyric acid tau siv rau hauv kev lag luam pub tsiaj kom txhim kho kev noj qab haus huv ntawm txoj hnyuv thiab kev ua haujlwm ntawm tsiaj. Muaj ntau tiam neeg tshiab tau raug qhia los txhim kho kev tuav cov khoom thiab nws cov kev ua tau zoo txij li thaum thawj zaug sim tau ua nyob rau hauv xyoo 1980.

1 Kev tsim cov butyric acid ua cov khoom noj khoom haus ntxiv

Xyoo 1980 > Butyric Acid siv los txhim kho kev loj hlob ntawm cov rumen
Xyoo 1990> cov ntsev ntawm butyrin acid siv rau kev txhim kho kev ua tau zoo ntawm tsiaj
Xyoo 2000s> cov ntsev uas tau tsim los: muaj cov hnyuv zoo dua thiab muaj ntxhiab tsawg dua
Xyoo 2010> Ib qho esterified butyric acid tshiab thiab ua haujlwm tau zoo dua tau qhia tawm

Niaj hnub no kev ua lag luam yog tswj hwm los ntawm cov butyric acid uas muaj kev tiv thaiv zoo. Cov neeg tsim khoom noj uas ua haujlwm nrog cov khoom ntxiv no tsis muaj teeb meem nrog cov teeb meem tsw thiab cov nyhuv ntawm cov khoom ntxiv rau kev noj qab haus huv thiab kev ua tau zoo dua. Txawm li cas los xij, qhov teeb meem nrog cov khoom coated ib txwm muaj yog qhov concentration qis ntawm butyric acid. Cov ntsev coated feem ntau muaj 25-30% butyric acid, uas yog qis heev.

Qhov kev tsim kho tshiab tshaj plaws hauv cov khoom noj khoom haus butyric acid yog kev tsim kho ntawm ProPhorce™ SR: glycerol esters ntawm butyric acid. Cov triglycerides ntawm butyric acid no tuaj yeem pom muaj nyob rau hauv mis nyuj thiab zib ntab. Lawv yog qhov chaw zoo tshaj plaws ntawm cov butyric acid tiv thaiv nrog qhov concentration ntawm butyric acid txog li 85%. Glycerol muaj chaw rau peb lub butyric acid molecules txuas rau nws los ntawm qhov hu ua 'ester bonds'. Cov kev sib txuas muaj zog no muaj nyob rau hauv txhua lub triglycerides thiab lawv tsuas yog tuaj yeem tawg los ntawm cov enzymes tshwj xeeb (lipase). Hauv cov qoob loo thiab lub plab, cov tributyrin tseem nyob ruaj khov thiab hauv txoj hnyuv qhov twg pancreatic lipase muaj nyob rau hauv, cov butyric acid raug tso tawm.

Cov txheej txheem ntawm esterifying butyric acid tau ua pov thawj tias yog txoj hauv kev zoo tshaj plaws los tsim cov butyric acid tsis muaj ntxhiab uas raug tso tawm qhov twg koj xav tau: hauv plab hnyuv. Qhov sib txawv nrog cov ntsev coated tau teev nyob rau hauv daim duab 2.

Ntawm ESPN thib 20 hauv Prague, kev tshawb fawb sib piv tau nthuav tawm txog cov nyhuv ntawm 2 cov khoom sib txawv butyric acid raws li cov khoom ntxiv hauv cov qaib ntxhw. Kev sim tau ua nyob rau ntawm ADAS chaw tshawb fawb hauv UK xyoo 2014. Lawv piv cov ntsev sodium coated (nrog 68% txheej) nrog ProPhorce™ SR 130 (55% butyric acid). 720 Coss308 tus qaib txiv neej tau muab faib ua 3 pawg, nrog 12 lub qhov ntawm 20 tus noog ib pawg. Txhawm rau ua raws li cov xwm txheej lag luam kom ze li sai tau, cov khib nyiab qias neeg tau ntxiv tom qab kev ntsuam xyuas kab mob parasitological, kab mob thiab kab mob viral.

Kev ua haujlwm ntawm Tributyrin

1. Kho cov kab mob me me hauv plab hnyuv ntawm cov tsiaj thiab tiv thaiv cov kab mob hauv plab hnyuv.

2. Txhim kho kev nqus thiab kev siv cov as-ham.

3. Yuav txo tau kev raws plab thiab kev ntxhov siab ntawm cov tsiaj hluas.

4. Ua rau cov tsiaj hluas muaj sia nyob ntev dua thiab hnyav dua txhua hnub.