Nyob rau xyoo tas los no, ntau thiab ntau "cov tog neeg koom ua ke" tau tshwm sim hauv kev lag luam saib xyuas tawv nqaij. Lawv tsis mloog cov lus tshaj tawm thiab cov neeg sau blog zoo nkauj cog nyom raws li lawv xav tau, tab sis kawm thiab nkag siab txog cov khoom xyaw zoo ntawm cov khoom saib xyuas tawv nqaij ntawm lawv tus kheej, yog li ntawd thiaj li xaiv cov khoom saib xyuas tawv nqaij uas haum rau lawv.

Nrog rau kev sib tw ua lag luam ntawm cov khoom siv tu tawv nqaij uas nce zuj zus, ntau lub npe lag luam tab tom nrhiav "cov khoom xyaw ntau dua" mus rau "cov khoom xyaw muaj txiaj ntsig". Cov khoom xyaw tu tawv nqaij uas txhawb nqa los ntawm cov thev naus laus zis dub tau nrov zuj zus, tsim kom muaj qhov xwm txheej uas "cov khoom xyaw tseem ceeb saib cov khoom xyaw, thiab cov khoom xyaw laus saib cov thev naus laus zis".

Ua tib zoo mloog cov khoom tshiab ntawm cov hom lag luam hauv tsev thiab txawv teb chaws, thiab pom tias cov hom lag luam no tab tom ua kom nrawm dua cov khoom siv raw thiab thev naus laus zis, yog li cov khoom tshiab tuaj yeem nyiam cov neeg siv khoom ntau dua, thiab thev naus laus zis tshiab tuaj yeem coj kev lag luam nkag mus rau txoj kev tshiab. Kev nce qib ntawm pawg neeg tshawb fawb thiab thev naus laus zis yog qhov tseeb ntawm kev sib koom ua ke sab hauv rau cov kws kho kom zoo nkauj.

Daim ntawv qhia txog kev siv science thiab technology hauv kev lag luam kev zoo nkauj xyoo 2025 qhia tau hais tias kev sib koom ua ke ntawm kev zoo nkauj thiab technology tab tom txhim kho tob zuj zus, thiab cov thev naus laus zis tshiab raws li kev tshawb fawb txog tsiaj txhu yuav txuas ntxiv pab R & D thiab tsim cov khoom zoo nkauj tshiab. Kev lag luam kev zoo nkauj uas siv science thiab technology yuav ua rau muaj kev tawg, thiab qhov loj ntawm kev ua lag luam yuav ncav cuag li 1 trillion yuan txog xyoo 2025.

 

Kev tshawb fawb thiab kev txhim kho ntawm cov tshuaj nano tau dhau los ua qhov kev coj ua tseem ceeb ntawm lub zej zog kho mob thiab tshuaj thoob ntiaj teb tam sim no, thiab kev siv cov qauv tshiab ntawm liposomes thiab vesiclespharmaceutical npaj cov thev naus laus zis xws li nano carrier technology hauv cov tshuaj pleev ib ce tau raug txhawb nqa thiab txhawb nqa los ntawm lub xeev.

Vim tias cov tawv nqaij ntawm tib neeg nyuaj rau nkag mus rau hauv, kev noj haus nyuaj rau ncav cuag cov txheej tob ntawm daim tawv nqaij, uas cuam tshuam loj heev rau kev siv cov khoom siv saib xyuas daim tawv nqaij. Cov thev naus laus zis Nanocarrier tau tshwm sim raws li lub sijhawm xav tau, feem ntau daws cov teeb meem ntawm kev xa khoom, kev tso tshuaj qeeb, kev nqus transdermal thiab lwm yam. Cov nanocarriers feem ntau siv suav nrog liposomes, hydrogel carriers, micelles, microcapsules, kua siv lead ua kua, supramolecules, thiab lwm yam.

Kev siv cov nanocarriers los xa cov khoom xyaw ua haujlwm zoo rau kev saib xyuas tawv nqaij mus rau hauv cov chaw thiab cov hlwb ntawm daim tawv nqaij los ntawm kev xa khoom mus rau daim tawv nqaij, tso tawm qeeb thiab kav ntev, daws tau qhov teeb meem kev lag luam ntawm cov tshuaj pleev ib ce uas nyuaj rau nqus los ntawm daim tawv nqaij. Nanocarriers kuj muaj cov haujlwm ntawm kev txhim kho qhov solubility thiab dej dispersibility ntawm cov khoom xyaw ua haujlwm ntawm cov tshuaj pleev ib ce tsis yaj, txhim kho kev ruaj khov ntawm cov khoom xyaw ua haujlwm rhiab rau lub teeb thiab kub, thiab txhim kho kev sib raug zoo ntawm cov khoom xyaw ua haujlwm.

Thaum ntxov li xyoo 1965, cov kws tshawb fawb Askiv Bangham thiab Standish tau pom tias phospholipids tuaj yeem tsim cov bilayer vesicles (micelle) hauv dej los ntawm electron microscopy, thiab hu lawv ua liposomes. Qhov no tau dhau los ua ib qho ntawm cov kev tshawb pom tseem ceeb hauv kev lag luam tshuaj hauv xyoo pua 20th.

Lub Hlaws ntawm lub kaus mom ntawm nanocarriers -- liposomes

Vim tias cov qauv yooj yim ntawm cov ntshav plasma membrane kuj yog ib daim phospholipid bilayer membrane, liposomes muaj cov qauv zoo ib yam li cov hlwb biological, yog li lawv muaj biocompatibility zoo, yog li lawv kuj hu ua "artificial biofilm". Liposomes siv qhov kev sib raug zoo no los ua tiav kev xa tshuaj lossis ua haujlwm tau zoo. Liposomes zoo tagnrho yuav tsum muaj histocompatibility zoo, tsis muaj tshuaj lom, tsim nyog encapsulation thiab tso tawm peev xwm.

Raws li lub npe qhia, cov khoom tseem ceeb ntawm liposomes yog "lipids". Cov liposomes feem ntau yog ua los ntawm phospholipids thiab cholesterol, uas yog cov tshuaj endogenous uas muaj nyob hauv cov kab mob, muaj kev sib raug zoo nrog cov ntaub so ntswg thiab tsis yog immunogenic.

Cov txheej txheem raw khoom rau liposomes

Lub npe lag luam ntawm cov khoom siv raw: kev tiv thaiv tiv thaiv kev laus liposome

Cov txheej txheem encapsulation sib xyaw: liposome + retinol + astaxanthin + coenzyme Q10

Cov khoom siv raw ua tau zoo: compact thiab wrinkle resistant

Kev siv pom zoo: 5% - 10%

Cov khoom siv tau: Dej Essence, essence, lub ntsej muag lub ntsej muag, gel, tshuaj pleev, tshuaj pleev