Cov khoom noj khoom haus ntxiv: Tributyrin

Cov ntsiab lus: 95%, 90%

Tributyrin ua ib qho khoom noj khoom haus ntxiv rau kev txhim kho kev noj qab haus huv ntawm cov nqaij qaib.

Kev tshem tawm cov tshuaj tua kab mob ua cov tshuaj txhawb kev loj hlob ntawm cov zaub mov pub qaib ua rau muaj kev txaus siab rau lwm txoj hauv kev noj zaub mov, rau kev ua kom cov qaib ua tau zoo dua thiab tiv thaiv kev mob nkeeg.

Txo qhov mob dysbacteriosis
Yuav kom tswj tau qhov teeb meem dysbacteriosis, cov khoom noj khoom haus xws li probiotics thiab prebiotics raug ntxiv los cuam tshuam rau kev tsim cov SCFAs, tshwj xeeb tshaj yog butyric acid uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev ua haujlwm ntawm txoj hnyuv. Butyric acid yog SCFA uas tshwm sim ntuj uas muaj ntau yam txiaj ntsig zoo xws li nws cov txiaj ntsig tiv thaiv kev o, nws cov txiaj ntsig los ua kom cov txheej txheem kho plab hnyuv sai dua thiab txhawb kev loj hlob ntawm cov plab hnyuv. Muaj ib txoj hauv kev tshwj xeeb butyric acid ua haujlwm los ntawm lub tshuab los tiv thaiv kev kis kab mob, uas yog Host Defense Peptides (HDPs) synthesis, tseem hu ua anti-microbial peptides, uas yog cov khoom tseem ceeb ntawm kev tiv thaiv kab mob. Lawv muaj cov haujlwm dav dav tiv thaiv kab mob tiv thaiv cov kab mob, fungi, parasites thiab enveloped viruses uas nyuaj heev rau cov kab mob los tsim kev tiv thaiv. Defensins (AvBD9 & AvBD14) thiab Cathelicidins yog ob tsev neeg tseem ceeb ntawm HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) pom muaj nyob rau hauv cov nqaij qaib uas tau txhawb nqa los ntawm butyric acid supplementation. Hauv kev tshawb fawb ua los ntawm Sunkara et. al. kev siv butyric acid los ntawm sab nraud ua rau muaj kev nce ntxiv ntawm HDP gene thiab ua rau muaj peev xwm tiv taus kab mob hauv cov qaib. Qhov nthuav yog, nruab nrab thiab LCFAs marginal.

Cov txiaj ntsig ntawm Tributyrin rau kev noj qab haus huv
Tributyrin yog ib qho ua ntej ntawm butyric acid uas tso cai rau ntau cov molecules ntawm butyric acid kom xa mus rau hauv txoj hnyuv me ncaj qha vim yog cov txheej txheem esterification. Yog li ntawd, qhov concentration yog ob mus rau peb zaug siab dua li cov khoom siv coated ib txwm muaj. Esterification tso cai rau peb cov molecules butyric acid kom khi rau glycerol uas tsuas yog tuaj yeem tawg los ntawm endogenous pancreatic lipase.
Li et. al. tau teeb tsa kev tshawb fawb txog kev tiv thaiv kab mob kom pom cov txiaj ntsig zoo ntawm tributyrin rau cov cytokines pro-inflammatory hauv cov qaib uas muaj LPS (lipopolysaccharide). Kev siv LPS tau lees paub dav dav tias ua rau muaj kev o hauv kev tshawb fawb zoo li no vim nws ua rau cov cim qhia txog kev o xws li IL (Interleukins). Nyob rau hnub 22, 24, thiab 26 ntawm kev sim, cov qaib tau raug sim nrog kev siv intraperitoneal ntawm 500 μg / kg BW LPS lossis saline. Kev noj zaub mov tributyrin ntxiv ntawm 500 mg / kg inhibited qhov nce ntawm IL-1β & IL-6 qhia tias nws cov khoom noj khoom haus ntxiv muaj peev xwm txo qhov kev tso tawm ntawm cov cytokines pro-inflammatory thiab yog li txo qis qhov mob plab.

Kev Txheeb Xyuas
Vim muaj kev txwv tsis pub siv lossis txwv tsis pub siv cov tshuaj tua kab mob uas ua rau cov tsiaj txhu loj hlob sai, yuav tsum tshawb nrhiav cov tswv yim tshiab los txhim kho thiab tiv thaiv kev noj qab haus huv ntawm cov tsiaj txhu hauv teb chaws. Kev ua haujlwm ntawm txoj hnyuv ua lub luag haujlwm tseem ceeb ntawm cov khoom siv raw khoom kim heev thiab kev txhawb nqa kev loj hlob hauv cov qaib ntxhw. Butyric acid tshwj xeeb yog lees paub tias yog ib qho tshuaj txhawb nqa kev noj qab haus huv ntawm txoj hnyuv uas twb tau siv rau hauv cov tsiaj txhu rau ntau tshaj 20 xyoo. Tributyrin xa cov butyric acid hauv txoj hnyuv me thiab muaj txiaj ntsig zoo rau kev cuam tshuam rau kev noj qab haus huv ntawm txoj hnyuv los ntawm kev ua kom cov txheej txheem kho txoj hnyuv sai dua, txhawb kev loj hlob zoo tshaj plaws thiab hloov kho cov tshuaj tiv thaiv kab mob hauv txoj hnyuv.

Tam sim no nrog rau cov tshuaj tua kab mob raug tshem tawm, butyric acid yog ib qho cuab yeej zoo los txhawb kev lag luam kom txo qhov cuam tshuam tsis zoo ntawm dysbacteriosis uas tab tom tshwm sim los ntawm qhov kev hloov pauv no.