Potassium formate, thawj cov khoom noj khoom haus uas tsis yog tshuaj tua kab mob uas tau pom zoo los ntawm European Union hauv xyoo 2001 thiab tau pom zoo los ntawm Ministry of Agriculture ntawm Tuam Tshoj hauv xyoo 2005, tau sau ib daim phiaj xwm thov uas laus dua rau ntau tshaj 10 xyoo, thiab ntau daim ntawv tshawb fawb hauv tebchaws thiab thoob ntiaj teb tau tshaj tawm txog nws cov teebmeem rau ntau theem ntawm kev loj hlob ntawm npua.

Kab mob Necrotizing enteritis yog ib yam kab mob thoob ntiaj teb uas tshwm sim los ntawm cov kab mob gram-positive (Clostridium perfringens), uas yuav ua rau cov qaib tuag ntau ntxiv thiab txo qhov kev loj hlob ntawm cov qaib hauv txoj kev tsis pom tseeb. Ob qho tib si no ua rau cov tsiaj txhu puas tsuaj thiab ua rau muaj kev puas tsuaj loj rau kev tsim qaib. Hauv kev tsim khoom tiag tiag, feem ntau cov tshuaj tua kab mob raug ntxiv rau hauv cov khoom noj kom tiv thaiv kev tshwm sim ntawm kab mob necrotizing enteritis. Txawm li cas los xij, kev hu rau kev txwv tsis pub siv tshuaj tua kab mob hauv cov khoom noj nce ntxiv, thiab lwm yam kev daws teeb meem yog qhov xav tau los hloov cov txiaj ntsig tiv thaiv ntawm cov tshuaj tua kab mob. Kev tshawb fawb pom tias kev ntxiv cov organic acids lossis lawv cov ntsev rau hauv cov khoom noj tuaj yeem tiv thaiv cov ntsiab lus ntawm Clostridium perfringens, yog li txo qhov tshwm sim ntawm kab mob necrotizing enteritis. Potassium formate raug rhuav tshem mus rau hauv formic acid thiab potassium formate hauv txoj hnyuv. Vim yog cov khoom sib txuas covalent rau qhov kub thiab txias, qee cov formic acid nkag mus rau hauv txoj hnyuv tag nrho. Qhov kev sim no siv cov qaib uas muaj kab mob necrotizing enteritis ua tus qauv tshawb fawb los tshawb xyuas cov teebmeem ntawmcov qauv poov tshuajntawm nws txoj kev loj hlob, cov kab mob hauv plab hnyuv, thiab cov roj fatty acid luv luv.

1. Cov Nyhuv ntawmPotassium Diformatentawm Kev Loj Hlob ntawm Cov Broilers Uas Muaj Kab Mob Necrotizing Enteritis.

Cov txiaj ntsig ntawm kev sim qhia tau hais tias potassium formate tsis muaj qhov cuam tshuam loj rau kev loj hlob ntawm cov qaib broilers nrog lossis tsis muaj kab mob necrotizing enteritis, uas yog sib xws nrog cov txiaj ntsig tshawb fawb ntawm Hernandez et al. (2006). Nws tau pom tias tib koob tshuaj calcium formate tsis muaj qhov cuam tshuam loj rau qhov hnyav nce txhua hnub thiab qhov sib piv ntawm cov khoom noj ntawm cov qaib broilers, tab sis thaum ntxiv calcium formate mus txog 15 g / kg, nws txo qis kev loj hlob ntawm cov qaib broilers (Patten thiab Waldroup, 1988). Txawm li cas los xij, Selle et al. (2004) pom tias ntxiv 6 g / kg ntawm potassium formate rau hauv cov zaub mov ua rau qhov hnyav nce thiab noj zaub mov ntawm cov qaib broiler ntau ntxiv 16-35 hnub. Tam sim no muaj ob peb daim ntawv tshawb fawb txog lub luag haujlwm ntawm cov organic acids hauv kev tiv thaiv kab mob necrotizing enteritis. Qhov kev sim no pom tias ntxiv 4 g / kg potassium formate rau hauv cov zaub mov ua rau txo qis kev tuag ntawm cov qaib broilers, tab sis tsis muaj kev sib raug zoo ntawm cov koob tshuaj ntawm kev txo qis kev tuag thiab qhov ntau ntawm potassium formate ntxiv.

2. Cov nyhuv ntawmPotassium Diformatentawm Cov Kab Mob Me Me hauv Cov Nqaij thiab Cov Kab Mob ntawm Cov Qe Nqaij Uas Muaj Kab Mob Necrotizing Enteritis

Qhov ntxiv ntawm 45mg/kg bacitracin zinc rau hauv cov zaub mov pub txo qhov kev tuag ntawm cov broilers uas muaj tus kab mob necrotizing enteritis, thiab tib lub sijhawm txo cov ntsiab lus ntawm Clostridium perfringens hauv jejunum, uas yog sib xws nrog cov txiaj ntsig tshawb fawb ntawm Kocher et al. (2004). Tsis muaj qhov cuam tshuam tseem ceeb ntawm kev noj zaub mov potassium diformate ntxiv rau cov ntsiab lus ntawm Clostridium perfringens hauv jejunum ntawm broilers uas muaj tus kab mob necrotizing enteritis rau 15 hnub. Walsh et al. (2004) pom tias cov zaub mov acidity siab muaj qhov tsis zoo rau cov organic acids, yog li ntawd, cov acidity siab ntawm cov zaub mov protein siab yuav txo qhov cuam tshuam ntawm potassium formate rau necrotizing enteritis. Qhov kev sim no kuj pom tias potassium formate ua rau cov ntsiab lus ntawm lactobacilli ntau ntxiv hauv cov leeg nqaij ntawm 35d broiler qaib, uas tsis sib xws nrog Knarreborg et al. (2002) pom hauv vitro tias potassium formate txo qhov kev loj hlob ntawm lactobacilli hauv lub plab npua.

3.Cov nyhuv ntawm potassium 3-dimethylformate rau cov ntaub so ntswg pH thiab cov roj fatty acid luv luv hauv cov qaib broiler uas muaj kab mob necrotizing enteritis

Cov tshuaj tua kab mob ntawm cov organic acids ntseeg tau tias feem ntau tshwm sim hauv qhov chaw sab saud ntawm txoj hnyuv zom zaub mov. Cov txiaj ntsig ntawm qhov kev sim no qhia tau tias potassium dicarboxylate ua rau cov tshuaj formic acid ntau ntxiv hauv duodenum thaum 15 hnub thiab jejunum thaum 35 hnub. Mroz (2005) pom tias muaj ntau yam uas cuam tshuam rau kev ua haujlwm ntawm cov organic acids, xws li pH pub, buffering/acidity, thiab kev sib npaug ntawm cov electrolyte hauv cov zaub mov. Cov acidity qis thiab cov nqi electrolyte siab hauv cov zaub mov tuaj yeem txhawb kev sib cais ntawm potassium formate mus rau hauv formic acid thiab potassium formate. Yog li ntawd, qib acidity thiab electrolyte sib npaug hauv cov zaub mov tuaj yeem txhim kho kev txhim kho kev loj hlob ntawm cov broilers los ntawm potassium formate thiab nws cov txiaj ntsig tiv thaiv ntawm necrotizing enteritis.

Xaus lus

Cov txiaj ntsig ntawmcov qauv poov tshuajntawm tus qauv ntawm necrotizing enteritis hauv cov qaib broiler tau qhia tias potassium formate tuaj yeem txo qhov kev poob qis ntawm kev loj hlob ntawm cov qaib broiler nyob rau hauv qee qhov xwm txheej los ntawm kev nce qhov hnyav ntawm lub cev thiab txo qhov tuag, thiab tuaj yeem siv ua cov khoom noj khoom haus ntxiv los tswj kev kis tus kab mob ntawm necrotizing enteritis hauv cov qaib broiler.