Guanylacetic acid, tseem hu ua guanylacetic acid, yog ib qho amino acid analogue tsim los ntawm glycine thiab L-lysine.

Guanylacetic acid tuaj yeem tsim cov creatine nyob rau hauv cov catalysis ntawm cov enzymes thiab yog tib qho yuav tsum tau ua rau kev tsim cov creatine. Creatine raug lees paub tias yog lub zog buffer, thiab nws lub luag haujlwm tseem ceeb yog los tsim cov phosphorylated creatine nyob rau hauv qhov kev ua ntawm creatine kinase.

Koom nrog kev mus ncig ua si adenosinelub voj voog ntawm cov tshuaj phosphate (ATP). Thaum lub zog ATP tsis txaus, phosphocreatine hloov cov pab pawg phosphate mus rau adenosine diphosphate sai sai los ntawm creatine kinase thiab hloov nws rov qab mus rau adenosine triphosphate.

 

Daim ntawv thov rau cov tsiaj txhu:

Ntxiv 0.12%, 0.08%, thiab 0.04% guanylacetic acid rau hauv cov zaub mov ntawm 120 tus yaj Tan uas pub rau hauv lub tsev cog khoom uas hnyav li 20 kilograms, qhia tau tias qhov ntxiv 0.12% thiab 0.08% guanylacetic acid ua rau qhov hnyav nce txhua hnub, cov rog hauv cov leeg, thiab cov protein ntau ntxiv, thiab txo cov rog hauv lub cev.

 

Ntxiv ntawm 0.08%guanylacetic acidnce feem pua ​​ntawm cov nqaij ntshiab los ntawm 9.77%. Los ntawm kev siv txoj kev tsim roj hauv vitro, cov txiaj ntsig ntawm kev ntxiv ntau qib ntawm guanylacetic acid rau ntawm rumen ntawm cov nyuj daj tau kawm. Nws tau pom tias qhov ntxiv ntawm 0.4% guanylacetic acid ua rau muaj roj ntau ntxiv, thiab qhov concentration ntawm ammonia nitrogen ua ntej nce thiab tom qab ntawd txo qis.

Yog li ntawd, nws tuaj yeem xaus lus tias kev ntxiv guanylacetic acid rau hauv cov khoom noj txhua hnub tuaj yeem txhim kho qhov chaw ib puag ncig sab hauv ntawm rumen thiab hom kev fermentation ntawm cov nyuj daj.

Daim ntawv thov hauv cov nqaij qaib:

Ntxiv 800 mg/kg, 1600 mg/kg, 4000 mg/kg, thiab 8000 mg/kg ntawm guanylacetic acid rau cov khoom noj txhua hnub ntawm cov broilers qhia tau tias ntxiv 800-4000 mg/kg ntawm guanylacetic acid rau cov khoom noj ua rau cov broilers hnyav zuj zus txhua hnub, txo qhov sib piv ntawm cov khoom noj rau qhov hnyav ntawm cov broilers thaum muaj hnub nyoog 22-42 hnub. Ntxiv 8000 mg/kg ntawm guanylacetic acid txhim kho cov ntsuas biochemical hauv cov ntshav xws li urea nitrogen, cov ntsuas ntshav niaj hnub, thiab tag nrho bilirubin Tsis muaj kev cuam tshuam loj rau cov ntsuas lub cev tseem ceeb, qhia tias ntxiv 8000 mg/kg ntawm guanylacetic acid rau cov khoom noj txhua hnub ntawm cov broilers yog tolerable.

Ntxiv 200 mg/kg, 400 mg/kg, 600 mg/kg, thiab 800 mg/kg ntawm guanylacetic acid rau hauv cov zaub mov broiler qhia tau tias qhov hnyav nruab nrab nce ntxiv txhua hnub ntau dua piv rau pawg tswj. Cov txiaj ntsig zoo tshaj plaws tau ua tiav thaum cov qib ntxiv yog 600 thiab 800 mg/kg.

Yuav kawm txog qhov cuam tshuam ntawm guanylacetic acid rau qhov zoo ntawm cov phev hauv cov qaib, 20 tus qaib hnub nyoog 28 lub lis piam tau raug xaiv los pub cov khoom noj uas muaj 0%, 0.06%, 0.12%, thiab 0.18% guanylacetic acid. Cov txiaj ntsig tshawb fawb pom tias kev ntxiv 0.12% guanylacetic acid rau hauv cov khoom noj ua rau cov phev ntau ntxiv, cov phev concentration, thiab cov phev ua haujlwm hauv cov qaib ntau ntxiv, qhia tias kev ntxiv guanylacetic acid rau hauv cov khoom noj tuaj yeem txhim kho qhov zoo ntawm cov phev. Ntxiv 0.0314%, 0.0628%, 0.0942%, thiab 0.1256% guanylacetic acid rau cov khoom noj txhua hnub ntawm cov qaib ntxhw, thiab teeb tsa ob pawg tswj (pawg tswj 1 yog cov khoom noj uas ua los ntawm cov nroj tsuag tsis muaj cov tshuaj ntxiv, thiab pawg tswj 2 yog cov khoom noj uas muaj ntses ntxiv). Rau pawg ntawm cov khoom noj txhua hnub saum toj no muaj tib theem ntawm lub zog thiab cov zaub mov.

Cov txiaj ntsig ntawm kev sim qhia tau hais tias qhov hnyav nce ntawm plaub pawg nrog guanylacetic acid ntxiv thiab pawg tswj 2 yog siab dua li cov ntawm pawg tswj 1, Pawg tswj 2 muaj qhov hnyav nce zoo tshaj plaws, ua raws li 0.0942% guanylacetic acid pawg; Pawg tswj 2 muaj qhov sib piv ntawm cov khoom siv zoo tshaj plaws rau qhov hnyav, ua raws li 0.1256% guanylacetic acid pawg.

Daim ntawv thov hauv cov nqaij qaib:

Ntxiv 800 mg/kg, 1600 mg/kg, 4000 mg/kg, thiab 8000 mg/kg ntawmguanylacetic acidrau cov khoom noj txhua hnub ntawm cov qaib ntxhw tau qhia tias ntxiv 800-4000 mg / kg ntawm guanylacetic acid rau hauv cov khoom noj ua rau cov qaib ntxhw nce qhov hnyav txhua hnub, txo qhov sib piv ntawm cov khoom noj rau qhov hnyav ntawm cov qaib ntxhw thaum muaj hnub nyoog 22-42 hnub. Ntxiv 8000 mg / kg ntawm guanylacetic acid txhim kho cov ntsuas biochemical hauv cov ntshav xws li urea nitrogen, cov ntsuas ntshav niaj hnub, thiab tag nrho bilirubin Tsis muaj kev cuam tshuam tseem ceeb rau cov ntsuas lub cev tseem ceeb, qhia tias ntxiv 8000 mg / kg ntawm guanylacetic acid rau cov khoom noj txhua hnub ntawm cov qaib ntxhw yog qhov ua tau. Ntxiv 200 mg / kg, 400 mg / kg, 600 mg / kg, thiab 800 mg / kg ntawm guanylacetic acid rau hauv cov khoom noj broiler tau qhia txog kev nce qhov hnyav nruab nrab txhua hnub piv rau pawg tswj. Cov txiaj ntsig zoo tshaj plaws tau ua tiav thaum cov qib ntxiv yog 600 thiab 800 mg / kg.

Yuav kawm txog qhov cuam tshuam ntawm guanylacetic acid rau qhov zoo ntawm cov phev hauv cov qaib, 20 tus qaib hnub nyoog 28 lub lis piam tau raug xaiv los pub cov khoom noj uas muaj 0%, 0.06%, 0.12%, thiab 0.18% guanylacetic acid. Cov txiaj ntsig tshawb fawb pom tias kev ntxiv 0.12% guanylacetic acid rau hauv cov khoom noj ua rau cov phev ntau ntxiv, cov phev concentration, thiab cov phev ua haujlwm hauv cov qaib ntau ntxiv, qhia tias kev ntxiv guanylacetic acid rau hauv cov khoom noj tuaj yeem txhim kho qhov zoo ntawm cov phev. Ntxiv 0.0314%, 0.0628%, 0.0942%, thiab 0.1256% guanylacetic acid rau cov khoom noj txhua hnub ntawm cov qaib ntxhw, thiab teeb tsa ob pawg tswj (pawg tswj 1 yog cov khoom noj uas ua los ntawm cov nroj tsuag tsis muaj cov tshuaj ntxiv, thiab pawg tswj 2 yog cov khoom noj uas muaj ntses ntxiv). Rau pawg ntawm cov khoom noj txhua hnub saum toj no muaj tib theem ntawm lub zog thiab cov zaub mov. Cov txiaj ntsig ntawm kev sim qhia tau hais tias qhov hnyav nce ntawm plaub pawg nrog guanylacetic acid ntxiv thiab pawg tswj 2 yog siab dua li cov ntawm pawg tswj 1, Pawg tswj 2 muaj qhov hnyav nce zoo tshaj plaws, ua raws li 0.0942%guanylacetic acidpawg; Pawg tswj 2 muaj qhov sib piv zoo tshaj plaws ntawm cov khoom siv rau qhov hnyav, ua raws li 0.1256% guanylacetic acid pawg.